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Native Septic Arthritis testing includes White Blood Cell (WBC) count with differential, which is an automated, high-performance cell count that provides overall number of white blood cells, as well as the percentage breakdown of white blood cell type in synovial fluid.��

• All counts >3,000 confirmed with a manual count��
• If the final reported WBC count is >3,000 cells/μL��or neutrophils percent is >70%, specimens are reflexed to the��Synovasure��Alpha Defensin for Native Septic Arthritis (NSA) test��

The Synovasure Alpha Defensin for NSA test examines the levels of the alpha defensin biomarker and lactate in synovial fluid.��

The alpha defensin biomarker has shown to be highly accurate in diagnosing the presence of periprosthetic joint infection¹��and is unaffected by:��

• Prior Antibiotic Administration^2,3
  
• History of Inflammatory Conditions^2,4
• Type/Virulence of Organism^2,5

Note: Validation and performance of alpha defensin is based on cases of PJI and has not been defined for NSA due to no comparative “Gold Standard” criterion.

The first laboratory test to aid in the diagnosis of OA, Synovasure OA testing includes assessment of Cartilage Oligomeric Matrix Protein (COMP) and Interleukin-8 (IL-8) concentration levels in synovial fluid.

• Only laboratory test available to aid in the diagnosis of isolated, idiopathic OA
• Utilization of COMP/IL-8 ratio to differentiate primary versus secondary OA patients
  • Increased IL-8 shows higher likelihood of inflammatory condition compared to OA��
• Highly Accurate⁶
  • 87.0% Sensitivity
  • 88.9% Specificity��

Rheumatoid Arthritis diagnostic testing includes synovial fluid assessment of inflammatory biomarkers concentrations commonly tested via blood – Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Rheumatoid Factor (RF).

• Testing closer to the knee pain source – synovial fluid vs. blood
  
• Sufficiently capable to discriminate RA and Non-RA patients⁶
• Effective “Rule-In” Test^6��
  • Demonstrated 100% specificity